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RMD Open publishes original research on rheumatic and musculoskeletal disorders and connective tissue diseases, including osteoporosis, spine and rehabilitation. It is an online only journal that aims to provide rapid publication of research through a continuous publication model and is free to read.
The effect of rituximab on patient reported outcomes in the …
Objectives Early treatment of individuals at risk of developing rheumatoid arthritis (RA-risk) in the preclinical phase has the potential to positively impact both patients and society by preventing disease onset and improving patients’ quality of life. The PRAIRI study was a randomised, double-blind, placebo-controlled trial with the B-cell depleting agent rituximab (RTX), which resulted in ...
Cardiovascular risk according to genetic predisposition to gout ...
Objective Recent studies have reported that gout is associated with a risk of cardiovascular disease (CVD) later in life. However, the predictive value of genetic predisposition to gout combined with lifestyle habits for CVD risk remains unclear. This study aimed to examine the association between genetic predisposition to gout and lifestyle habits and the risk of developing CVD in two diverse ...
EULAR/ACR classification criteria for adult and juvenile idiopathic ...
Objective To describe the methodology used to develop new classification criteria for adult and juvenile idiopathic inflammatory myopathies (IIMs) and their major subgroups. Methods An international, multidisciplinary group of myositis experts produced a set of 93 potentially relevant variables to be tested for inclusion in the criteria. Rheumatology, dermatology, neurology …
Li SWS, et al. RMD Open 20239:e003688 doi:101136rmdopen-2023-003688 1 REVIEW Treatment and monitoring of SAPHO syndrome: a systematic review Sophie W S Li,1 Eve Roberts,1 Christian Hedrich 1,2 To cite: Li SWS, Roberts E, Hedrich C. Treatment and monitoring of SAPHO syndrome:
Health technology assessment: a framework - RMD Open
Learn about the concept, purpose and types of health technology assessment (HTA), a multidisciplinary process that informs health policy decisions. HTA often involves economic evaluation, which compares costs and consequences of different health technologies.
Adami G, et al. RMD Open 2239:e292 doi:1113rmdopen222292 1 ORIGINAL RESEARCH Tapering glucocorticoids and risk of flare in rheumatoid arthritis on biological disease-modifying antirheumatic drugs (bDMARDs)
Long-term outcomes in patients with polyarticular juvenile …
Objectives Long-term safety and efficacy of adalimumab among patients with juvenile idiopathic arthritis (JIA) was evaluated through 6 years of treatment. Methods Children aged 4–17 years with polyarticular JIA were enrolled in a phase III, randomised-withdrawal, double-blind, placebo-controlled trial consisting of a 16-week open-label lead …
Methotrexate treatment hampers induction of vaccine-specific …
Methods In the current study, we investigated the impact of MTX treatment in patients with immune-mediated inflammatory disease on B and CD4 T cell SARS-CoV-2 vaccination responses. Eighteen patients with RA and two patients with psoriatic arthritis on MTX monotherapy were included, as well as 10 patients with RA without immunosuppressive treatment, and 29 healthy controls.
Impact of patient characteristics on ASDAS disease activity state …
Nov 3, 2024 · Objectives To re-evaluate cut-offs for disease activity states according to the Axial Spondyloarthritis Disease Activity Score (ASDAS), and study the impact of sex, age, calendar time, disease and symptom duration on ASDAS and ASDAS cut-offs in a large contemporary cohort. Methods Data from 2939 patients with axial spondyloarthritis (axSpA) starting their first tumour necrosis factor inhibitor ...