Nuclear-Targeted Drug Delivery of TAT Peptide-Conjugated …
Mar 15, 2012 · However, nuclear-targeted drug delivery is expected to kill cancer cells more directly and efficiently. In this work, TAT peptide has been employed to conjugate onto …
Multivalency Effect of TAT-Peptide-Functionalized Nanoparticle …
In this report we demonstrate the effective circumvention of multidrug resistance in cancer cells by an active nuclear-targeted drug delivery system that was constructed by conjugating TAT …
Potent latency reversal by Tat RNA-containing nanoparticle …
Dec 18, 2023 · Here, we explore the reactivation capacity of a lipid nanoparticle containing Tat mRNA (Tat-LNP) in CD4 T cells from people living with HIV undergoing antiretroviral therapy …
Nucleus-targeting near-infrared nanoparticles based on TAT …
Jan 15, 2020 · TAT peptide-conjugated IR780 (TAT-IR780) was synthesized. TAT-IR780 and doxorubicin (DOX) self-assembled to form TID nanoparticles. TID nanoparticles exhibited …
Vault Nanoparticles Engineered with the Protein Transduction …
In this study, we demonstrate that recombinant vaults, with the addition of a cell penetration peptide, TAT, can be rapidly delivered to cells in vitro with significantly elevated binding and …
Cellular internalization of bystander nanomaterial induced by TAT ...
Aug 13, 2019 · We find that T-NP internalization enables cellular uptake of bystander NPs, but not common fluid markers, through a receptor-dependent macropinocytosis pathway. Moreover, …
TAT-modified redox-sensitive nanoparticles for triggered drug …
Jun 1, 2020 · In this paper, an effective redox-responsive TAT-DSPE-PEG/PEI-SS-PLA/DOX (TPSPD) nanoparticle was developed, which achieved the expected an antitumor effect. The …
Lipid-based nano delivery of Tat-peptide conjugated drug or …
The HIV-1 TAT-peptide 47-57 (GRKKRRQRRRP), a short cationic (8 positive charges) and high content of essential amino acid (2 lysine and 6 arginine), rapidly became a popular and …
mRNA lipid nanoparticle formulation, characterization and
Mar 11, 2025 · Lipid nanoparticles have emerged as leading candidates for encapsulating mRNA drugs and have shown success in in vivo applications. ... such as HIV-TAT 1 (TAT, trans …
TAT-Modified Gold Nanoparticles Enhance the Antitumor Activity …
Sep 10, 2020 · To enhance the antitumor activity, the PAD4 inhibitor 356 was modified by the well-established cationic penetrating peptide RKKRRQRRR (peptide TAT) and gold …