Aug 23, 2023 · Nerve cells that sense touch grow the appropriate endings for hairy or hairless skin based on cues from the skin itself, rather than through predetermined programming, according to research led by Harvard Medical School scientists and published Aug. 21 in Developmental Cell.

Apr 11, 2024 · A tickly itch, a painful scratch, or the feeling of a refreshing breeze—the skin is teaming with nerve endings that drive these sensations. Scientists are getting into the epidermis to explore how skin and nerve cells interact.

Skin cells: dermal fibroblast and keratinocytes. Due to the availability of discard skin, most tissue-engineered models utilize primary human skin cells. The only exception to date for the innervated skin models is Gingras et al., 50 who developed an innervated model with all primary murine cells. This reduces any species difference that occurs ...

A dense network of sensory nerves releases neuropeptides, thereby modulating inflammation, cell growth, and the immune responses in the skin. Neurotrophic factors, in addition to regulating nerve growth, participate in many properties of skin function.

The skin cells produce classic hormones and neurotransmitters including neuropeptides that act on their receptors through para-, auto-, and intracrine mechanisms, which in turn regulate local homeostasis (Fig. 1A).

Aug 1, 2022 · Inflammatory skin diseases are orchestrated by primary sensory neurons and immune cells. Specialized subsets of primary sensory neurons promote skin repair. Neuroimmune pathways reveal new therapeutic targets for skin diseases.

Feb 3, 2020 · Current strategies to create skin appendages and sensory nerve regeneration are mainly based on different types of seeding cells, scaffold materials, bioactive factors and involved signaling pathways.

Apr 11, 2021 · The skin is home to an array of sensory nerve endings and specialized immune cells, both with heterogeneous functionality. Neuroimmune interplay between sensory nervous system and the immune system in the skin is crucial in homeostasis and disease states.

The nervous system has been found to regulate physiological and pathological processes in the skin: cellular growth and differentiation, immune and inflammatory responses, and wound healing. The skin nerve fibers and inflammatory cells

Aug 21, 2023 · All layers and appendages of the skin are densely innervated by afferent and efferent neurons providing sensory information and controlling skin perfusion and sweating.