During development from hematopoietic stem cells, human NK cells acquire a repertoire of activating and inhibitory receptors that regulate NK‐cell function in different tissues, …

NK cells provide rapid responses to virus -infected cells, stressed cells, tumor cells, and other intracellular pathogens based on signals from several activating and inhibitory receptors.

Feb 18, 2019 · NK cells play important roles in innate defenses against viruses and in the control of tumor growth and metastasis. The regulation/induction of NK cell function is mediated by an …

NK cells are cytotoxic components of innate lymphoid cells (ILC) that provide a first line of defense against viral infections and contribute to control tumor growth and metastasis. Their …

NK cells recognize self and nonself depending on the balance of activating receptors and inhibitory receptors. After binding to their ligands, NK cell receptors trigger subsequent …

In this review, we provide a general overview of human NK cells, as opposed to murine NK cells, discussing their ontogeny, maturation, receptor diversity, types of responses, and effector …

Three distinct receptor families, Ly49, CD94/NKG2, and KIR, are involved in NK cell recognition of polymorphic MHC class I molecules. A common pathway of inhibitory signaling is provided by …

Natural killer (NK) cells are innate lymphocytes that play a crucial role in the early response to infection or malignant transformation. Under these conditions, NK cells are activated and …

Sep 1, 2000 · All NK-cell inhibitory receptors are characterized by the presence of an immunoreceptor tyrosine-based inhibition motif (ITIM) in their cytoplasmic tail. Importantly, …

NK cells play important roles in innate defenses against viruses and in the control of tumor growth and metastasis. The regulation/induction of NK cell function is mediated by an array of …