Gene editing therapeutics based on mRNA delivery
Sep 1, 2023 · We introduce gene editing therapeutics using mRNA and focus on engineering and improvement of gene editing technology. We subsequently examine ex vivo and in vivo gene …
Gene editing therapeutics based on mRNA delivery - PubMed
We introduce gene editing therapeutics using mRNA and focus on engineering and improvement of gene editing technology. We subsequently examine ex vivo and in vivo gene editing …
When mRNA meets gene editing | Nano Research - Springer
Jun 1, 2024 · This review focuses on mRNA-based delivery of gene editing agents, highlighting novel mRNA delivery systems. To provide context, a comparison is made between three main …
When mRNA meets gene editing - SciOpen
This review focuses on mRNA-based delivery of gene editing agents, highlighting novel mRNA delivery systems. To provide context, a comparison is made between three main gene editing …
mRNA therapy at the convergence of genetics and nanomedicine
Mar 17, 2023 · Several mRNA-based gene editing tools, such as zinc-finger nucleases, transcription activator-like effector nucleases (TALEN) and clustered regularly interspaced …
Optimizing 5’UTRs for mRNA-delivered gene editing using deep …
Jun 20, 2024 · We experimentally test designed 5’UTRs with mRNA encoding megaTAL TM gene editing enzymes for two different gene targets and in two different cell lines. We find that the …
mRNA and gene editing: Late breaking therapies in liver diseases
In this review we summarize the preclinical data obtained in animal models treated with mRNA as a therapeutic agent and discuss the different gene editing strategies applied to the treatment …
Genome Editing with mRNA Encoding ZFN, TALEN, and Cas9
Effective delivery of the mRNA encoding genome-editing nucleases and their corresponding partners (e.g., sgRNA for CRISPR and donor template DNA for targeted insertion) is the key …
Gene Editing – UC Berkeley Department of Bioengineering
Jan 17, 2025 · Murthy lab and UC Davis have developed a unique mRNA delivery method for in-utero gene editing for neurodevelopmental conditions. Thermostable Cas9 Enhances RNP …
Shoot the messenger: RNA editing is here - Nature Biotechnology
Mar 6, 2023 · RNA editing is rapidly gaining prominence as its transient and reversible changes promise a safer and more flexible option to reverse disease-causing mutations than DNA editing.