Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized ...

Ribosomes, often referred to as the cell's protein factories, translate messenger RNA (mRNA) into a specific sequence of amino acids, in a process referred to as translation.

Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

Professor Hirohide Saito and his research team have developed a new approach to control mRNA translation using Cas proteins, thus expanding the variety of mRNA switches and making it easier to ...

This new technique enables researchers to monitor an individual ribosome over time during mRNA translation. Using their technique, the team already gained new insights into how ribosomes function.

Here, the mRNA sequence is decoded in the process of translation into an amino acid sequence, the basic building blocks of proteins, and synthesized into amino acid chains. SKI complex: consists of ...

When the team tested the multi-tailed mRNAs in human cells, they sustained mRNA translation much longer than both natural mRNA and mocRNA, producing up to 20 times more proteins per dose over time.

Researchers presented challenges related to the clinical translation of messenger ribonucleic acid (mRNA) technology, recent innovations and future directions to improve the clinical efficacy of ...

Local translation makes sense from a logistics point of view. A single mRNA transcript can produce numerous protein copies, labor that the cell body can outsource to far away regions in the neuron.

Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.