Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

Sartorius Stedim Biotech and Sensible Biotechnologies are scaling up a unique cell-based manufacturing platform for ...

The cellular transcription, mRNA processing and export machineries seem to have co-evolved to allow spatiotemporal coupling of these processes. Here, the author reviews recent insights into the ...

Now, researchers from Kyushu University have revealed that the smallest known protein-based tRNA-processing enzyme, called ...

The application of genomic technologies to the study of mRNA processing is increasingly conducted in metazoan organisms in order to understand the complex events that occur during and after ...

A Closer Look At mRNA Process Development Challenges. A more detailed examination of mRNA process development (Figure 1) uncovers several areas for improvement across multiple steps.

To build proteins, cells rely on a molecule called transfer RNA, or tRNA. tRNAs act like protein-building couriers, where ...

RNA methylation. Of the ~100 post-transcriptional chemical modifications to RNA known, N 6-methyladenosine (m 6 A) is the most prevalent modification in mRNA. Although described over 40 years ago, ...

But, as scientists look to model every aspect of mRNA processing, publicly available data on tangential flow filtration (TFF) is noticeably absent.

The mRNA market is projected to reach $63.28 billion by 2025, indicating an all-time high global demand for mRNA vaccines and therapeutics. Now more than ever, robust process development and ...

However, while working in the late Susan Lindquist’s lab at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, Khurana turned up connections to mRNA translation and ...