Panelists discuss how the pathophysiology of pulmonary arterial hypertension involves complex mechanisms across multiple genetic and treatment pathways, with over 20 identified genes and four ...

Pulmonary fibrosis: Nerandomilast inhibits phosphodiesterase 4B, may treat multiple forms of disease by Catholic University of the Sacred Heart edited by Stephanie Baum, reviewed by Andrew Zinin ...

Phosphodiesterase 4B inhibition: a potential novel strategy for treating pulmonary fibrosis. Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases. Rolipram attenuates bleomycin A5 ...

Are you a healthcare provider looking for information on sickle cell disease (SCD) pathophysiology? Read about SCD pathophysiology here.

This review addressed erectile dysfunction, regarding pathophysiology and therapeutic strategies. The line of treatment includes phosphodiesterase type-5 inhibitors and other types of therapy like ...

In these mice, expression of PDE2 (cGMP-stimulated phosphodiesterase) was increased and PDE2 gained a stronger impact on NO-induced cGMP as analysed by the FRET-based cGMP indicator cGi-500.

Identification of Novel Quinolone and Quinazoline Alkaloids as Phosphodiesterase 10A Inhibitors for Parkinson’s Disease through a Computational Approach Iqra Ahmad ...

WASHINGTON -- Treatment with the first-in-class dual phosphodiesterase 3/4 inhibitor ensifentrine reduced exacerbation rates and improved other key outcomes in patients with chronic obstructive ...

The present review focuses on Phosphodiesterase-1 and its isoforms, splicing variants, location, distribution, and function; the role of Phosphodiesterase-1 inhibitors in Alzheimer’s disease; and the ...

Phosphodiesterase 5 inhibitors (eg, sildenafil, tadalafil) do not appear to reduce the risk of Alzheimer disease and related dementias, according to an NIH study.

MILAN — A basket study of a new topical phosphodiesterase 4 inhibitor demonstrated efficacy superior to that of placebo in mild to moderate plaque psoriasis. PF-07038124, an oxaborole-based ...

"Small, randomized, pharmacologic studies have reported an amplified decrease in blood pressure during controlled coexposure with nitrates and [phosphodiesterase type 5 inhibitors], both in ...