PDE5 inhibitors typically include sildenafil, tadalafil, vardenafil, and avanafil. They differ in how long before they take effect, in cost, and in their common side effects.

The association between melanoma among PDE5i users was only statistically significant for male patients with low PDE5i exposure and with low-stage melanoma.

Phosphodiesterase 5 (PDE5) inhibitors appear to be effective in treating Raynaud's phenomenon secondary to scleroderma, investigators concluded at the 2015 ACR/ARHP Annual Meeting.

The PDE5 inhibitors were predominantly distributed in the prostate. [69] These findings may help to support the feasibility of using PDE5 inhibitors to treat LUTS.

The phosphodiesterase type-5 (PDE5) inhibitors sildenafil, vardenafil and tadalafil are widely used first-line therapy for erectile dysfunction (ED). Since the advent of sildenafil in 1998, more ...

Discover how phosphodiesterase-4 (PDE-4) inhibitors manage inflammation in people with mild to severe plaque psoriasis.

PDE5 inhibitors lower the activity of PDE5 by competing with cGMP and consequently raise the level of cGMP. In the absence of stimulation of the NO pathway, PDE5 inhibition is ineffective.

In a comparison of two erectile dysfunction medications in men with stable CAD, phosphodiesterase type 5, or PDE5, inhibitors were associated with better survival and outcomes compared with ...

There is a class of drugs called “Phosphodiesterase-5 inhibitors” (PDE5 inhibitors.) Such drugs in this class are known as sildenafil, vardenafil, tadalafil, and avanafil.1 These drugs all work by ...

Sildenafil citrate did not improve perinatal outcomes compared with placebo in a trial with more than 3,000 patients. Phosphodiesterase type 5 (PDE5) inhibitors like sildenafil citrate may prevent ...

Aimed at improving cancer therapeutics, a doctorate student at Purdue University, Lukman Bello has published research on the rational design and optimisation of novel PDE5 inhibitors for targeted ...

The Recent PDE5 Inhibitors: Sildenafil, Tadalafil & Vardenafil in Male ED Since the early 1980s and 1990s, the physiology and pathophysiology of erectile function and dysfunction have been ...