PDE5 inhibitors are a group of medications typically used to treat physiological causes of erectile dysfunction (ED). Learn about the most common types of PDE5 inhibitors, how they work and how ...

Administration of the PDE5 inhibitors in daily doses of 50 or 100 mg (sildenafil), 5 or 20 mg (tadalafil), 100 or 200 mg (udenafil), 40 or 100 mg (UK-369.003) or 10 or 20 mg (vardenafil ...

The phosphodiesterase type-5 (PDE5) inhibitors sildenafil, vardenafil and tadalafil are widely used first-line therapy for erectile dysfunction (ED). Since the advent of sildenafil in 1998, more ...

Phosphodiesterase 5 (PDE5) inhibitors are useful for the treatment of erectile dysfunction (ED), and a wide variety of chemotypes have shown activity as PDE5 inhibitors. PDE5 inhibitors work in ...

PDE5 Inhibitor More Effective When Used On-demand In Erectile Dysfunction, Study Shows Date: August 26, 2008 Source: Elsevier Summary: A new study shows for the first time that vardenafil, a PDE5 ...

Patients with pulmonary arterial hypertension at intermediate risk who switched from phosphodiesterase type 5 inhibitors to riociguat experienced clinical improvement at 24 weeks, according to ...

They found that from a baseline of 26 attacks per week, the PDE5 inhibitors reduced frequency of these attacks by 4.2 per week (95% confidence interval [CI]: 2.01, 6.38), a relative reduction of ...

There is a class of drugs called “Phosphodiesterase-5 inhibitors” (PDE5 inhibitors.) Such drugs in this class are known as sildenafil, vardenafil, tadalafil, and avanafil.1 These drugs all work by ...

Long-term, continuous administration of phosphodiesterase type 5 inhibitors may be a safe and effective treatment for CVD, according to a new report in BMC Medicine.Researchers conducted a meta ...

Table 1. Pharmacokinetic properties of the recent, clinically meaningful PDE5 inhibitors. PDE5 inhibitor Time to maximum plasma concentration (t max, h) Elimination half-life time (t ½, h ...