In the Phase III SELECT-GCA trial, Rinvoq (upadacitinib) 15 mg with a 26-week glucocorticoid taper significantly improved ...

Panelists discuss how advancements in understanding myeloproliferative neoplasms are shaping treatment approaches through case studies of intermediate-risk myelofibrosis and advanced polycythemia vera ...

Recent research sheds light on how changes in the chemical structure of a protein called Interleukin-6 affect lung cancer’s ...

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal ...

T-PLL is molecularly defined by TCL1A or MTCP1 rearrangements, often accompanied by ATM mutations and JAK/STAT pathway activation. Immunophenotyping reveals CD4+/CD8+ coexpression and ...

J Mol Cell Biol 13: 556-564. 15. Zhang Y, Zhou X, Liu P, et al. (2021): GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells ...

This study sought to determine whether the SOCS3/JAK/STAT3 signaling pathway, which controls macrophage polarization, contributes to the cardiotoxicity caused by PD-1/PD-L1 inhibitors. The PD-1/PD-L1 ...

Janus kinase (JAK) inhibitors were associated with more infections, particularly herpes infections, in patients with atopic dermatitis (AD) compared with biologics, in a cohort study. A ...

COL1A1, COL1A2 proteins, Activin, and Pai1 genes are targets of TGF-β. Additionally, IL-6 and IL-17 can induce COL1A1 transcription through the JAK-STAT3 signaling pathway (76). Connective tissue ...

Zhejiang Provincial Key Lab for Chemical and Biological Processing Technology of Farm Product, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou ...

Besides, CAFs-derived MMPS contribute to ECM degradation. IL-6 secreted from CAFs promotes the release of SOCS3 and various pro-tumor molecules via JAK/STAT, MAPK and PI3K pathway. Tumor-derived VEGF ...

The depletion of peripheral Vδ2 T cells and their increased infiltration into involved tissues underscores their potential role in the pathogenesis of IgG4-RD. Notably, JAK/STAT3 inhibition attenuated ...