By reconstituting eukaryotic DNA replication in vitro, this study addresses the effects of physiological quadruplex secondary structures on genome stability. G‐quadruplexes (G4s) and intercalated ...

With the accumulation of genomic data, it is increasingly clear that eukaryotic genes do not randomly distribute in chromosomes. In this study, we investigated the distribution of 27142 genes mapped ...

University of Cincinnati Cancer Center researchers looked billions of years into the past to learn more about the potential ...

In the dim waters off the Japanese coast, scientists have stumbled upon something that shouldn’t exist. Or at least not by the rules we thought biology followed. While sequencing DNA from a tiny ...

By using a genetic technique developed at UT Southwestern Medical Center that forces cells to rid themselves of mitochondria, researchers are gaining new insights into the function of these critical ...

A single-step deamination sequencing method was developed for genome-wide mapping of 5hmC at single-base resolution.

It is now established that genome size is not related to organismal complexity (C-value enigma) or the number of coding genes n eukaryotes. Rather, variation in DNA content depends on the amount of ...

The translocation of DNA in polymerase (Pol) enzymes is a critical step for Pol-mediated nucleic acid polymerization, essential for storing and transmitting genetic information in all living organisms ...