"An exciting finding was when we tried to treat the obese mice with colon inflammation by lowering their inflammation, it actually stopped the ERK pathway in the liver from activating," explains Imai.

Developing sector transition pathways and providing attractive risk return is key to delivering finance that can support the UK deliver its net zero goal whilst also driving economic growth, experts ...

A total of 337 treatment-naïve patients with EGFR-sensitive mutation-positive locally advanced or metastatic NSCLC were enrolled and randomized 1:1 to receive either limertinib or gefitinib.

Top officials offer few details of how Washington might de-escalate damaging tariff war US President Donald Trump on Wednesday played up prospects of a "fair deal" on trade with China, but his top ...

1 Center of Gerontology and Geriatrics and Laboratory of Metabolism ... Our findings demonstrate that DAPA can inhibit the MAPK signaling pathway, as confirmed by network pharmacology analysis and ...

Uncovering methylation signatures and pathways associated with resistance to anti-EGFR therapy in colorectal cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual ...

The expression of TLS-associated genes in CD4+ T cells was significantly elevated, along with the upregulation of immune-related pathways, such as B cell activation signaling and IL-17-related ...

Department of Histology and Embryology, Faculty of Medicine, Suleyman Demirel University, Isparta 32260, Turkey Department of Histology and Embryology, Faculty of Medicine, Ege University, Izmir 35100 ...

NMPA Key Laboratory for Research and Evaluation of Drug Metabolism, Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, 1023 ...

Previous studies have indicated that BRAF inhibitors alone do not achieve satisfactory outcomes, as they can lead to feedback activation of EGFR and reactivation of the MAPK pathway ... and HRAS (1%).