The 30S ribosomal subunit has a crucial role in decoding mRNA by monitoring base pairing between the codon on mRNA and the anticodon on transfer RNA; the 50S subunit catalyses peptide-bond formation.

These findings suggest that the rigidity of the anticodon stem-loop is finely tuned by modifications, where rigidity in the anticodon arm is essential for tRNA translocation in the ribosome, and ...

To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

Intrinsic tryptophan fluorescence spectroscopy is an important tool for examining the effects of molecular crowding and confinement on the structure, dynamics, and function of proteins. Synthetic ...

eLife Assessment In this valuable study, Roiuk et al combined ribosome profiling and reporter assays to provide compelling evidence that eIF2A does not have a major impact on mRNA translation in HeLa ...

Although eIF2A is thought to be a translation initiation factor, loss of eIF2A has no effect on cellular mRNA translation in either unstressed or stressed conditions.

The identification of SLC35F2 as the eukaryotic transporter of queuine and queuosine is key to understanding how these micronutrients are salvaged from the human gut and distributed to different body ...