Scientists have discovered that tRNAs can determine how long mRNAs exist in a cell, causing some messages to be stabilized ...

When mRNA is no longer needed, ... In doing so, they reveal an important function of the supercomplex: connecting the translation of an mRNA by the ribosome and its destruction through the exosome.

Here, the mRNA sequence is decoded in the process of translation into an amino acid sequence, the basic building blocks of proteins, and synthesized into amino acid chains. SKI complex: consists of ...

Researchers explored how the incorporation of N1-methylpseudouridine (1-methylΨ) into mRNAs affects ribosomal frameshifting and the overall fidelity of mRNA translation.

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

Summary: New research reveals how a tiny chemical mark on RNA helps wire the brain during development. Scientists discovered ...

By unraveling the dynamics of mRNA translation, researchers can gain deeper insights into cellular processes and the role of protein synthesis in health and disease. RELATED TOPICS.

The main hurdles for mRNA clinical translation are the stability, translation efficiency, and immunostimulatory potential of exogenous mRNA.

Professor Hirohide Saito and his research team have developed a new approach to control mRNA translation using Cas proteins, thus expanding the variety of mRNA switches and making it easier to ...

When the team tested the multi-tailed mRNAs in human cells, they sustained mRNA translation much longer than both natural mRNA and mocRNA, producing up to 20 times more proteins per dose over time.

Aberrant mRNA translation is a prominent feature in many neurodegenerative diseases. The pathological hallmark is abnormally folded protein aggregates, with a unique molecular composition.