How does a cell know when it’s been damaged? A molecular alarm, set off by mutated RNA and colliding ribosomes, signals ...

Antibody–siRNA conjugates (ARCs) are a type of promising drug modalities for cancer therapy. However, initial reports of ARCs present the gene knockdown effect only in limited tissues (e.g., muscles) ...

DNA makes RNA, RNA makes protein, protein makes phenotype—was the guiding framework for understanding inheritance and disease ...

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...

Researchers discovered a previously unknown function of RNA, potentially opening the door to new ways to treat cancer and neurodegenerative diseases.

A new type of mRNA vaccine is more scalable and adaptable to continuously evolving viruses such as SARS-CoV-2 and H5N1, according to a study by researchers at the University of Pittsburgh School ...

Company to share updates at the AACR and ASGCT annual meetings BOSTON--(BUSINESS WIRE)--#AACR2025--Strand Therapeutics Inc., the programmable mRNA company developing curative therapies for cancer and ...

mRNA vaccines train the immune system in a similar way to traditional vaccines, but they use a different strategy to get there.

mRNA is synthesized by the enzyme RNA polymerase. This occurs by using the sequence of bases in a DNA strand to create a complementary mRNA strand.

This process repeats along the length of the mRNA strand until the ribosome runs into a stop codon, a special sequence of three nucleotides that signals the end of the protein-making instruction ...

Protein synthesis is vital for life, translating genetic information from DNA to functional proteins through transcription and translation processes.

Once delivered to a muscle cell, the gene is transcribed into mRNA and the ribozyme activates, cutting itself off of the strand and leaving behind the chemical footprint the cell recognizes.