Advancements in manufacturing technologies is a key driver driving nucleic acid therapeutics CDMO market revenue growth.

No longer a mere assistant who carries out the commands of DNA, RNA takes the lead in emerging therapeutics.

Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

In a study of human immune cells infected with HIV, the virus that causes AIDS, scientists at Johns Hopkins Medicine say a ...

Scientists have discovered the internal shape of tiny drug-delivery particles – called lipid nanoparticles – has a big impact ...

Moreover, mRNA specific sequence and secondary structure or subtle environmental changes are also key determinants to take into account. To sum up, the whole understanding of such a fine tuned ...

By tethering RNA polymerase with the coupling transcription factor NusG or its paralog or version, RfaH, which threads the ...

FOR IMMEDIATE RELEASE “Zwitterionic Polymer-Functionalized Lipid Nanoparticles for the Nebulized Delivery of mRNA” Journal of the American Chemical Society Most people don’t enjoy getting shots for ...

Siloxane nanoparticles unlock precise organ targeting for mRNA therapy Changes to chemical structure allow for tissue-specific delivery Date: October 1, 2024 Source: University of Pennsylvania ...

By adjusting the chemical structure of lipid nanoparticles, the researchers were able to target different organs, presaging a new era in precision medicine. Credit: Lulu Xue and Michael J. Mitchell ...

They tested mRNA structures with zero to three branches and three different kinds of chemical modifications. The modifications were phosphorothioate (PS), DNA, and 2’-O-methoxyethyl (2MOE).

My collaborators and I are exploring other types of solids that might not need such low temperatures. We’re also looking at ways to temporarily change the mRNA chemical structure to keep it from ...