NT219, a novel dual inhibitor of IRS1/2 and STAT3, is being evaluated in a Phase 2 study in patients with recurrent and/or ...

Cancer patients invariably develop resistance to targeted drugs, so drugmakers develop strategies to combat it before ...

The frequency of high blood glucose among patients receiving PI3K/Akt inhibitors to treat breast cancer has some oncologists ...

Anaplastic thyroid cancer (ATC), a rare yet highly aggressive malignancy, continues to represent a major clinical challenge.

Zhejiang Provincial Key Lab for Chemical and Biological Processing Technology of Farm Product, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou ...

In the published article, there was an error in the Funding statement. The funding statement in the article is written incorrectly as “Jilin Provincial Science and ...

We are investigating the mechanisms by which cancer mutations deregulate the normal processes of cellular function and growth ...

Moreover, the expression levels of 606 genes appeared to be significantly modulated by miltirone via RNA-seq analyses, and PI3K/AKT signaling pathway was found to refer to miltirone activity.

Although anti-epidermal growth factor receptor (EGFR) therapy has established efficacy ... The GSEA revealed significant enrichment in 53 KEGG and 33 Reactome pathways, including MAPK-related and Akt ...