DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. Its function is based on two ...

Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at ...

“Topoisomerase II is essential for cell survival ... “What you want to do is combine it with something else that has a different function. For example, current therapies for myeloma ...

ALE.P02 has a potentially first-in-class tubulin inhibitor payload, while ALE.P03 features a topoisomerase I inhibitor ... that aims to restore the function of the protein UNC13A, which is ...

MHB009C comprises a human IgG1 antibody against B7-H4, conjugated to the SuperTopoi TM payload, a novel DNA topoisomerase I inhibitor that is 3∼5 times more potent than DXd, with a drug-antibody ratio ...

Abstract 1679, under the session ‘Drug Combination Strategies for Cancer Treatment’, showed that APG-2449, a novel focal ...

Claudin-6 (CLDN6), a member of the claudin family, is localized in the tight junctions of epithelial cells to regulate permeability, barrier function and polarity ... CLDN9 conjugated to Qilu’s ...