We designed a lentiviral vector expressing a chimeric antigen receptor with specificity for the B-cell antigen CD19, coupled with CD137 (a costimulatory receptor in T cells [4-1BB]) and CD3-zeta (a ...

Identification of the AAV receptor and vector-specific reagents has led to the development of purification protocols for rAAV vectors by affinity (receptor/antibody) matrix chromatography.

Adeno-associated virus (AAV) is a promising vector for human somatic gene therapy. However, its broad host range is a disadvantage for in vivo gene therapy, because it does not allow the selective ...

However, clinical studies have demonstrated poor efficacy of adenoviral gene therapy because of the absence of adenoviral binding sites on pancreatic cancer cells such as the coxsackie and ...

The study by Huang and colleagues describes the evaluation of an AAV vector engineered to actively enter the brain via transferrin receptor (TfR)-mediated transcytosis. This route to enter the brain ...

As putting the transgene into the cell gets easier, scale-up, which is the next hurdle, looms large.

Now, a Harvard University team led by renowned geneticist and serial biotech entrepreneur George Church, Ph.D., has developed a way to "cloak" AAVs from immune surveillance by inhibiting the ...

Graphic illustration of DRG-101 (DeltaRex-G). This Chimeric Antigen Receptor Vector (CAR-V) displays a Sig targeting peptide on its gp70 env (A), for binding to Signature (Sig) Proteins in the ...

New conditionally replicative adenovirus vector with synNotch receptor gene for MIBC treatment March 25, 2025 The MIBC subtype accounts for around 25% of all BC cases, with a significant proportion of ...

Chimeric antigen receptor–modified T cells with specificity for CD19 have ... signaling domain and is expressed with the use of lentiviral-vector technology. 10 Here we report the use of CTL019 ...