Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic enzyme that mainly represses transcription of target genes via symmetric dimethylation of arginine residues on histones H4R3 ...

The study “Identification of SARS CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase” is available as a preprint on the bioRxiv* server ...

Both LSD1 and the protein lysine methyltransferase (PKMT) ... Chang, Y. et al. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nature Struct. Mol.

A recent study posted to bioRxiv* identified inhibitors for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 14 (Nsp14). Study: Structure-based discovery of ...

Paper citied: "Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity," Nature Communications. DOI: 10.1038/s41467-021-23152-6 Journal ...

Protein arginine N-methyltransferase 5 (PRMT5) inhibitors have been disclosed in an Abbisko Therapeutics Co. Ltd. patent and described as potentially useful for the treatment of cancer.

Amgen Inc. has described tricyclic-amido-bicyclic compounds acting as protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of cancer.

Tango Therapeutics has dosed the first subject in the Phase I/II trial assessing TNG462 in combination with Revolution Medicines' daraxonrasib or zoldonrasib for methylthioadenosine phosphorylase ...

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nature Communications , 2021; 12 (1) DOI: 10.1038/s41467-021-23152-6 Cite This Page : ...

Anti-leukemia activity of histone deacetylase (HDAC) inhibitor LBH589 involves depletion of EZH2 and DNA methyltransferase (DNMT) 1 through disruption of their chaperone association with heat shock ...

Blocking a protein could help overcome cancer resistance to PARP inhibitors. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2021 / 04 / 210408153641.htm ...