Protein-protein interactions (PPIs) are crucial for various cellular activities and disease development, and modulating PPIs using small molecule inhibitors (PPIIs) has gradually become a promising ...

Protein arginine methyltransferase inhibition rescues polyGR 15 -induced toxicity in C9orf72-expanded motor neurons. Survival of spinal motor neurons 24 days post-plating following co-treatment with 1 ...

Scientists at GT Apeiron Therapeutics and Shanghai Apeiron Biotechnology Co. Ltd. have divulged protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of ...

Our preclinical findings indicate that p-AKT protein expression, rather than PTEN, may be a more reliable predictor of response to AKT inhibition combined with docetaxel. Using p-AKT as a parameter, ...

Protein–protein interactions are no longer considered undruggable because of the conceptual and technical advances that allow inhibitors to be generated using rational design principles and ...

Protein l -isoaspartyl methyltransferase (PIMT), found in abundance in brain, is known to repair abnormal isoaspartate residues, formed on aging, to the normal aspartate. Using various biophysical ...