Tango Therapeutics has dosed the first subject in the Phase I/II trial assessing TNG462 in combination with Revolution Medicines' daraxonrasib or zoldonrasib for methylthioadenosine phosphorylase ...

Scientists at GT Apeiron Therapeutics and Shanghai Apeiron Biotechnology Co. Ltd. have divulged protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of ...

Stroke is said to be the second leading cause of death worldwide after heart disease. To prevent the death of neurons in the ...

A study published in mBio details the vulnerability of coronaviruses to inhibitors of a small protein domain called Mac1, or the "macrodomain," found in all coronaviruses such as SARS-CoV-2 and ...

Lipid kinases are enzymes that play a critical role in both cell signaling and membrane trafficking by phosphorylating lipid ...

Lipid kinases are enzymes that play a critical role in both cell signalling and membrane trafficking by phosphorylating lipid molecules in the body. The inhibition of two of these lipid kinases, ...

The designed proteins block hemoglobin from binding ChuA, an outer membrane bacterial protein, helping to inhibit E. coli's growth.

While their functions are diverse, myosins are similar in structure. NMII is so much like cardiac myosin, which keeps the ...

For instance, the identification of a methyltransferase targeting valosin‐containing protein (VCP) has established a clear link between lysine methylation and the control of cell migration and ...

DNMT3A mutations emerged as potential biomarkers for enhanced immunotherapy benefit in non-small cell lung cancer.