This study investigates potential therapeutic targets for osteoporosis using a multiomics approach and explores the dual role of androgen receptor (AR) signaling in its pathophysiology. By analyzing ...

Phosphodiesterase 11 A full-length form, PDE11A4, contains 2 GAF domains and a catalytic domain. PDE11A hydrolyzes both cAMP and cGMP with similar Km values. 34–36 Although a cyanobacterial adenylyl ...

The use of isoenzyme-selective phosphodiesterase (PDE) inhibitors is considered a great opportunity to treat various diseases of the human urogenital tract.

The Recent PDE5 Inhibitors: Sildenafil, Tadalafil & Vardenafil in Male ED Since the early 1980s and 1990s, the physiology and pathophysiology of erectile function and dysfunction have been ...