Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

Professor Hirohide Saito (Department of Life Science Frontiers at CiRA / The University of Tokyo) and Assistant Professor ...

While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

The microRNA is located within a short segment called an intron, which gets spliced out of the gene when it is transcribed into mRNA.

Full complementarity between the miRNA and its target mRNA is not required, meaning that a specific miRNA can target multiple mRNAs, generally regulating multiple genes within a common pathway.

Researchers have identified cellular factors that regulate the delivery and stability of mRNA to expand the potential of mRNA therapeutics.

For example, they have characterized the transcriptome (mRNA, lncRNA, and miRNA) of aortas in an atherosclerosis mouse model, both during disease progression and after regression following treatment.

There are notable differences between men and women in their susceptibility to many human diseases, including cardiovascular disease. For example, women typically have smaller hearts that pump faster, ...

Results We identified six differentially expressed circRNAs in HCC, which were linked to 13 miRNAs and 88 mRNAs. A network containing 34 circRNA-miRNA pairs and 194 miRNA-mRNA pairs was constructed.

Victor Ambros received half of the Nobel Prize for his work on microRNAs. Here he talks about the teamwork – and the nematodes – that made the discovery possible.

MicroRNA binds to complementary sequences on target mRNA molecules, preventing or degrading them, resulting in reduced protein production.