Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

Therefore, if a microRNA-AGO complex engages with a certain mRNA, its corresponding protein will no longer be produced. That way genes are effectively silenced by microRNA "capturing" mRNA and ...

We are also beginning to use miRNA/protein pull-down to identify the precise miRNA-mRNA interactions, with the idea that miRNAs and their targets may form complexes with other RNA-binding proteins.

Here, we provide a detailed analysis of miRNA dysregulation in pediatric patients with AML, including expression patterns of previously annotated and novel miRNAs and identification of candidate miRNA ...

As such, the absolute number of potential mRNA targets within a cell for a single microRNA species could be very high (e.g. millions), raising the question of how a microRNA can effectively ...

Results. We identified six differentially expressed circRNAs in HCC, which were linked to 13 miRNAs and 88 mRNAs. A network containing 34 circRNA-miRNA pairs and 194 miRNA-mRNA pairs was constructed.

For example, they have characterized the transcriptome (mRNA, lncRNA, and miRNA) of aortas in an atherosclerosis mouse model, both during disease progression and after regression following treatment.

Identifying miRNA-mRNA network in CAFs and MSCs can show novel regulatory mechanisms for developing more effective therapeutic strategies targeting both cancer cells and their supportive ...

"We show for the first time that a microRNA-mRNA complex has a structure that changes and that this movement has an effect on the biological outcome, i.e. the amount of protein produced in the cell." ...

As diseases, including cancers, progress, changes in microRNA expression levels are observed. Specifically, in prostate cancer, the number of miR-93-5p microRNAs increases, and higher levels of ...