Rational design is the classical protein engineering method that involves site directed mutagenesis. 7 Scientists perform specific point mutations via insertions or deletions in the coding sequence ...

In fact, each gene in cellular DNA contains the code for a unique protein structure. Not only are these proteins assembled with different amino acid sequences, but they also are held together by ...

Amino acids have different side chains ... form long linear or fibrillar aggregates known as amyloid deposits. But how can a protein change so radically by folding differently, if the sequence ...