In the Phase III SELECT-GCA trial, Rinvoq (upadacitinib) 15 mg with a 26-week glucocorticoid taper significantly improved ...

Large granular lymphocytic leukemias (LGLLs) are a heterogeneous group of rare chronic lymphoproliferative disorders characterized by the clonal ...

T-PLL is molecularly defined by TCL1A or MTCP1 rearrangements, often accompanied by ATM mutations and JAK/STAT pathway activation. Immunophenotyping reveals CD4+/CD8+ coexpression and ...

Recent research sheds light on how changes in the chemical structure of a protein called Interleukin-6 affect lung cancer’s ...

J Mol Cell Biol 13: 556-564. 15. Zhang Y, Zhou X, Liu P, et al. (2021): GCSF deficiency attenuates nonalcoholic fatty liver disease through regulating GCSFR-SOCS3-JAK-STAT3 pathway and immune cells ...

This study sought to determine whether the SOCS3/JAK/STAT3 signaling pathway, which controls macrophage polarization, contributes to the cardiotoxicity caused by PD-1/PD-L1 inhibitors. The PD-1/PD-L1 ...

The researchers found that IL-6 activates what is called the JAK-STAT pathway in muscle, and this is what causes the reduced energy production of mitochondria. Several therapeutics already ...

Zhejiang Provincial Key Lab for Chemical and Biological Processing Technology of Farm Product, School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou ...

The depletion of peripheral Vδ2 T cells and their increased infiltration into involved tissues underscores their potential role in the pathogenesis of IgG4-RD. Notably, JAK/STAT3 inhibition attenuated ...

Besides, CAFs-derived MMPS contribute to ECM degradation. IL-6 secreted from CAFs promotes the release of SOCS3 and various pro-tumor molecules via JAK/STAT, MAPK and PI3K pathway. Tumor-derived VEGF ...