Recent research sheds light on how changes in the chemical structure of a protein called Interleukin-6 affect lung cancer’s ...

Panelists discuss how advancements in understanding myeloproliferative neoplasms are shaping treatment approaches through case studies of intermediate-risk myelofibrosis and advanced polycythemia vera ...

My lab is interested in identifying and analysing regulators of the JAK/STAT pathway– a signaling cascade frequently misactivated in haematopoietic malignancies. We use both high throughput RNAi ...

A recent study published by the lab in Nature Communications [2024; PMID: 38355560] sheds light on this aspect by elucidating the role of the IL6/JAK/STAT3 signaling pathway in driving bladder cancer ...

The study suggests that disturbances in the JAK-STAT signalling pathway, an important communication pathway in the body, may contribute to this side effect. “In the study, we uncover the ...

T-PLL is molecularly defined by TCL1A or MTCP1 rearrangements, often accompanied by ATM mutations and JAK/STAT pathway activation. Immunophenotyping reveals CD4+/CD8+ coexpression and ...

They found a protein called STAT3, key to a cell signaling pathway called JAK, at the center of activity in the seizure-affected mouse brains. "When we did a similar analysis of data from brain ...