Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression. Ferroptosis, driven by excessive lipid peroxides and iron-dependent ...

Limited penetration depth into tumor tissues continues to hinder the development of nanotherapeutics for cancer treatment. A novel self-propelled ferroptosis nanoinducer developed by Southern ...

Iron-dependent ferroptosis, a non-apoptotic cell death mechanism, is gaining attention for its role in immune suppression.

Junxia Min, Fudi Wang, et al., at Zhejiang University School of Medicine, China, provided an in-depth review on the programmed cell death known as ferroptosis, which is driven by iron-dependent ...

"Interestingly, in cancer cells that are less susceptible to ferroptosis, lipid peroxidation occurred in the lysosomes, but this did not lead to lysosomal membrane damage," continues Yamada. "Upon ...

A novel self-propelled ferroptosis nanoinducer was able to achieve deeper penetration into tumor tissues to show enhanced anti-cancer effects, while remaining considerable biocompatibility.