Methods: DNA double-strand break damage was induced with topoisomerase II inhibitor doxorubicin ... to evaluate the efficacy of peposertib in combination with doxorubicin in BON and QGP-1 ...

Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, ...

The FDA approved the PD-1 inhibitor penpulimab, with two indications, for treating non-keratinizing nasopharyngeal carcinoma (NPC) in adults. No trade name was indicated for the drug. The first ...

Among 103 patients in two cohorts (one group with rectal cancer and the other with non-rectal solid tumors) who completed treatment with the PD-1 inhibitor dostarlimab (Jemperli), 84 had a ...

GLP-1 RAs and SGLT2 inhibitors significantly reduce cardiovascular events and heart failure risk in older adults with type 2 diabetes compared to DPP-4 inhibitors. The study utilized health ...

HARMONi-6 is evaluating ivonescimab in combination with platinum-based chemotherapy compared with tislelizumab, a PD-1 inhibitor, in combination with platinum-based chemotherapy in patients with ...