Andrés Aguilera's laboratory, in collaboration with that of Ralf Wellinger (both professors in the Department of Genetics at ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, ...

Among 103 patients in two cohorts (one group with rectal cancer and the other with non-rectal solid tumors) who completed treatment with the PD-1 inhibitor dostarlimab (Jemperli), 84 had a ...

Pfizer has linked its PD-1 inhibitor to a 32% reduction in the risk of disease-related events in a phase 3 bladder cancer trial. But the study fell short of a clean sweep of positive outcomes ...

These promising preclinical results support the ongoing first-in-human phase 1 clinical trial of PF-08052666 in patients with advanced solid tumors (NCT06466187), which is currently enrolling ...

However, development has been paused. Management has said the planned Phase 2 trial (ZW49 plus PD-1 inhibitor in lung cancer) has been deprioritized while the company awaits clarity on the HER2 ...