The Incucyte ® Live-Cell Analysis System is a fully automated platform for phase contrast and two-color fluorescence imaging, ...

Gepotidacin inhibits bacterial DNA replication by a novel mechanism of action and binding site, blocking two different type II topoisomerase enzymes, and has shown activity in the lab against ...

NEWCASTLE, UK I April 25, 2025 I Iksuda Therapeutics (Iksuda), the developer of class leading, clinically validated antibody drug conjugates (ADCs) today announces that it will present three posters ...

Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, ...

Researchers from the University of Seville and PharmaMAR have discovered two natural compounds, patulin and xestoquinol, that inhibit the first catalytic step of DNA topoisomerase 1—an essential ...

For patients with cancers harboring certain genetic defects, the first-in-class targeted therapy RO7589831, which targets the ...

Neoadjuvant PD-1 blockade in dMMR tumors "could potentially eradicate the need for chemotherapy, radiation, and surgery in ...

Additionally, the combination treatment showed enhanced downregulation of oncogenic drivers and DNA methylation ... chemotherapy combined with topoisomerase inhibitors remains the standard of ...