“Anti-CD20 antibodies have demonstrated the ability to kill B lymphocytes in animal models and cause malignant cell lysis by activating complement- and antibody-dependent cellular toxicity (ADCC ...

Signals of the RTX antibody on a Raji B cell. It is easy to see how the antibody chains the CD20 molecules in the cell membrane, resulting in accumulations. The images were generated using the ...

WIL2-S-Luc2 CRL-8885-LUC2™ has been used as a target cancer cell for in vitro killing assay by CD19 CAR-T cells (tested at ATCC) and is expected to also work for CD20 CAR-T cells. WIL2-S-Luc2 has been ...

ADCC: Antibody-dependent cellular cytotoxicity; CDC: Complement-dependent cytotoxicity. Ofatumumab shows good efficacy in conditions with low CD20 expression and is approved for relapsed ...

Anti-CD20 mAbs evoke three main mechanisms of cell death: complement-dependent cell death (CDC); antibody-dependent cellular cytotoxicity (ADCC); and direct cell death (DCD). [71] Factors that ...