Short-circuitry of brown adipose mitochondria by proton leak through activated human uncoupling protein (UCP1) leads to heat production and this process is thought to be inhibited specifically by ...

Cancer cell antigen presentation, a requirement for immune-mediated tumor rejection, is induced by dihydroorotate dehydrogenase-inhibitor-mediated cancer cell pyrimidine nucleotide depletion via ...

A method for the conversion of pyrimidines into pyrazoles by a formal carbon deletion has been achieved guided by computational analysis. The pyrimidine heterocycle is the most common diazine in ...

Increase in the CDK activity results in uncontrolled tumor growth (Lee and Han, 2008). As per the reported literatures, pyrimidine fused with different heterocycles such as furan, thiophene, pyrrole, ...

Pyrimidine bases are components of many biological macromolecules including DNA and RNA and are essential for cell growth. Although mammalian cells can acquire pyrimidines from salvage pathways, most ...

Scientists have detected adenine and guanine in meteorites for decades and seen hints of uracil. But cytosine and thymine had remained elusive.

Figure 1 The pyrimidine metabolism in cells In mammal, pyrimidine synthesis is composed of de novo pathway and salvage pathway. The de novo synthesis pathway initiated with the generation from ...

Here, we demonstrate that endogenous oxidized guanine bases in G4 sequences and the subsequent activation of the base excision repair (BER) pathway drive the spatiotemporal formation of G4 structures ...

Naturally occurring modification of the canonical A, G, C, and T bases can be found in the DNA of cellular organisms and viruses from all domains of life. Bacterial viruses (bacteriophages) are a ...

6. Analogues of purine or pyrimidine bases and their derivatives Among substances with anti-tumor and anti-viral properties, some are artificial molecules obtained by modifying biological molecules ...