Cluster of differentiation 73 (CD73) converts adenosine 5′-monophosphate to immunosuppressive adenosine, and its inhibition was proposed as a new strategy for cancer treatment. We synthesized ...

On the basis of model imidazole inhibitors of cytokine release, a series of novel pyridinyl pyrimidine derivatives was prepared and tested on their ability to inhibit the release of tumor necrosis ...

In the wild card approach the Cs in the reference genome are replaced with the wild card ‘Y’ for pyrimidine bases and thus allows for the alignment of Cs (methylated Cs) and Ts (possibly unmethylated ...