To overcome the inherent challenge of translation termination interference caused by stop codon reprogramming in mammalian ...

The anticodon arm contains a three-base anticodon sequence for decoding the mRNA surrounded by other nucleotides that impact its efficiency and binding to aaRSs.

Our anticodon engineered tRNAs overwrite nonsense mutations that would otherwise result in truncated, nonfunctional proteins.

The ribosome brings 3′-aminoacyl-tRNA and 3′-peptidyl-tRNAs together to enable peptidyl transfer by binding them in two major ways. First, their anticodon loops are bound to mRNA, itself anchored at ...

Lead program in severe hemophilia A aims to establish anticodon engineered tRNAs as breakthrough treatment option for 20 percent of patients with premature termination codon (PTC)-driven factor ...

hC Bioscience today announced preclinical data supporting its lead program in severe hemophilia A at the World Federation of Hemophilia 2024 World Congress in Madrid, Spain. Lead program in severe ...

DNA translation is the term used to describe the process of protein synthesis by ribosomes in the cytoplasm or endoplasmic reticulum.

For phage-encoded tRNAs targeted in the anticodon itself, we observe that phages typically avoid encoding these tRNAs, further supporting the hypothesis that phage tRNAs are selected to be insensitive ...

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To evaluate the decoding of the new codon-anticodon interactions involving the NaM–TPT3 pair, they first investigated the incorporation of serine into GFP at position 151 (the TAC codon was replaced ...

The expression of QARS binding‐deficient anticodon stem‐loop mutant (Anti‐Mut1) has no effect on global protein translation or QARS levels (Figs 4 I and J, and, 5 C and D), and simultaneous ...