The San Francisco 49ers (6-10) are 4.5-point underdogs as they try to break their three-game losing streak in a matchup ...

While the San Francisco 49ers chances of a spot in the playoffs have been decided for some time now, their loss in Week 18 to ...

The San Francisco 49ers missed the playoffs entirely after making it to the Super Bowl last season. They will have some big ...

What channel is 49ers vs Cardinals game on today? How to watch San Francisco vs Arizona NFL Week 18 football game on TV, ...

DFS millionaire Mike McClure shares his top daily Fantasy football picks for San Francisco 49ers vs. Detroit lions on MNF ...

Talent-wise, the Lions' current unit is up there with some of the best offenses in NFL history, a list that includes the ...

Monday night’s loss ensured the 49ers stayed at the No. 11 pick with one week to go.

The Detroit Lions offensive foursome of Gibbs, Montgomery, St. Brown and Williams makes NFL season history in win over 49ers ...

With the high-scoring contest against the 49ers, the Lions clinched their fifth game this season with 40 points and 0 ...

San Francisco 49ers running back Christian McCaffrey appeared in only four games this season. He missed the first eight due ...

After a challenging year leading the San Francisco 49ers, Kyle Shanahan delivered a subtle but reassuring message to fans, ...

Following Sunday's loss, all eyes have shifted to quarterback Brock Purdy's impending contract extension with the San Francisco 49ers.