The San Francisco 49ers (6-10) are 4.5-point underdogs as they try to break their three-game losing streak in a matchup ...

While the San Francisco 49ers chances of a spot in the playoffs have been decided for some time now, their loss in Week 18 to ...

The San Francisco 49ers missed the playoffs entirely after making it to the Super Bowl last season. They will have some big ...

There wasn’t much to play for when the San Francisco 49ers and Arizona Cardinals suited up Sunday at State Farm Stadium. The ...

San Francisco 49ers running back Christian McCaffrey appeared in only four games this season. He missed the first eight due ...

After a challenging year leading the San Francisco 49ers, Kyle Shanahan delivered a subtle but reassuring message to fans, ...

Jauan Jennings’ ejection and Isaac Guerendo’s cart-off knee injury added to the 49ers’ season-long macabre in Sunday’s 47-24 ...

Now that the NFL's regular season has ended, for most football fans, the next big event on their radar is Super Bowl 59.

Brock Purdy expresses his eagerness to quickly finalize his contract extension with the 49ers, aiming to avoid distractions and return to work.

Murray’s blooming connection with Harrison and tight end Trey McBride gives the Cards something to look forward to next fall, ...

San Francisco 49ers' fullback Kyle Juszczyk was immediately hit with a dose of reality. His time with the team may be coming ...

Kyler Murray threw for 242 yards and four touchdowns, two to Greg Dortch, and the Arizona Cardinals beat the injury-depleted ...