REAL AD hints that blood markers can spot subtle cognitive decline. People who fluff a digital cognitive test have more ...

Immunoassay or Mass Spec? In secondary care, Lumipulse p-tau217 and MS p-tau217 or %p-tau217 are similarly accurate. In ...

Scientists see several important uses for staging. For example, it can steer people more precisely to appropriate treatments.

For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation ...

Evidence suggests that in Parkinson’s disease, a breakdown in lysosomal function allows lipids to build up within cells. Variants of the GBA1 gene, the strongest genetic risk factor for sporadic PD, ...

A new consortium aims to speed the pace of basic science discovery in AD and related diseases. A future AI assistant is to ...

Vaccine Step Down. A person’s probability of developing dementia over seven years increased with age. It was higher in the ...

Some clinical trials for treatments that nip Alzheimer’s disease in the bud rely on recruiting carriers of autosomal-dominant mutations who will develop Alzheimer’s disease in a predictable fashion.

Tau PET correlates closely with cognitive decline in Alzheimer’s disease, making it a potential surrogate outcome measure. Yet in amyloid immunotherapy trials to date, this signal has not always ...

Unger was able to nip calcium transients in the bud by injecting a “puff” of sTREM2 into the mouse brain with a pipette; this temporarily silenced nearby neurons, and it did so in wild-type or TREM2 ...