DNA topoisomerase 1 is an enzyme present in all organisms, essential for cell proliferation. Its function is based on two catalytic steps: firstly, it cuts and then relinks the DNA, thus relaxing ...

Levofloxacin inhibits bacterial topoisomerase IV and DNA gyrase (both ... chronic bacterial prostatitis, skin and skin structure infections. Inhalation anthrax (post-exposure): to reduce incidence ...