In the case of Strand’s lead anticancer treatment, the mRNA sequence contains elements that only switch translation on in the presence of microRNA biomarkers around tumors.

Here, the mRNA sequence is decoded in the process of translation into an amino acid sequence, the basic building blocks of proteins, and synthesized into amino acid chains. SKI complex: consists of ...

mRNA vaccines train the immune system in a ... starts reading an mRNA molecule at the wrong point of its sequence. ... prevent protein-making machinery from "slipping" around the mRNA strand.

The helicase in the SKI complex unwinds the mRNA into a linear strand. Once bound to the ribosome, the SKI complex can extract the mRNA and transfer it to the exosome where it can be degraded.

Professor Hirohide Saito and his research team have developed a new microRNA-responsive hybrid mRNA switch, enabling precise, ...

In addition, Strand is advancing a broader pipeline powered by the company’s first-in-class cell-type specific mRNA engineering platform, including advancing STX-003, an intravenously ...

We obtained optimal comb-structured RNA effectively activating RIG-I by changing the length and sequence of dsRNA. The resulting comb mRNA effectively ... dsRNAs bound to the mRNA strand, ...