"Its function: When m6A is attached to an mRNA, it triggers the degradation of the mRNA as soon as the first proteins have been produced according to the blueprint it contains. This is ...

mRNA degradation is a crucial process in eukaryotic cells that regulates gene expression by controlling the lifespan of messenger RNA (mRNA) molecules. This regulation is essential for maintaining ...

An evolutionarily conserved mRNA-degradation pathway is initiated by the removal of the 3′ poly(A) tail. This disrupts the translation initiation complex and provides degradative enzymes with ...

Unlike short-read methods, long-read nanopore sequencing was effective for full-length and fragmented mRNAs, which provided insight into mRNA degradation. “Because you're sequencing the whole molecule ...

In this review of RNA therapies, we paint an overview of what’s going on in a field that is addressing a number of diseases.

Yet, naked mRNA is unstable, prone to degradation, and poorly absorbed by cells, limiting its effectiveness. This makes the development of reliable delivery methods essential for the future ...

Despite these structural features, mRNA molecules are relatively unstable compared to DNA. They have a shorter lifespan and are prone to degradation by cellular enzymes called ribonucleases (RNases).

m6A is a chemical modification found on mRNA molecules. It regulates various cellular processes, including mRNA stability and degradation, and plays a role in controlling protein synthesis. The role ...

mRNA vaccines are a novel type of vaccine that use messenger RNA (mRNA) to induce an immune response against a specific pathogen. Unlike traditional vaccines that use weakened or inactivated viruses ...