Researchers have identified two natural compounds, patulin and xestoquinol, as new inhibitors of the enzyme topoisomerase 1, a key element in the correct functioning of DNA. The finding, published in ...

Researchers from the University of Seville and PharmaMAR have discovered two natural compounds, patulin and xestoquinol, that inhibit the first catalytic step of DNA topoisomerase 1—an essential ...

Insights into the function of DNA Topoisomerase VI (Topo VI) may provide a springboard for drug discovery and crop protection ...

Shanghai Yiweikang Pharmaceutical Co. Ltd. has divulged camptothecin derivatives acting as DNA topoisomerase I inhibitors reported to be useful for the treatment of cancer.