The Scientist2y
Targeting Leukemia with T Cells That Avoid Self-Destruction
In T cell cancers such as T cell lymphoblastic leukemia (TLL), this challenge arises from fratricide, CAR T cell self-destruction. 1–3 CAR T cells often share the same receptors as malignant T cells, ...
CAR T-cell therapy tricks cancer cells with decoy, increases treatment efficiency in B-cell acute lymphoblastic leukemia
B-cell acute lymphoblastic leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most ...
The Scientist4y
Baking Soda Boosts T Cells’ Ability to Fight Leukemia
Patients with acute myeloid leukemia who relapse after stem cell transplantation have just a small chance of survival: doctors can give them additional donor T cells to fight the cancer, but only ...
EurekAlert!7d
A new CAR-T-cell therapy that tricks the tumor could increase treatment efficiency in B-cell Acute Lymphoblastic Leukemia
Treatment of B-cell Acute Lymphoblastic Leukaemia has been greatly improved by CAR-T therapies, but relapse is still very common. An international team has now found in animal models a new approach ...
Nature8y
Fully human CD19-specific chimeric antigen receptors for T-cell therapy
The resulting CD19-CAR T-cells were specifically activated by CD19-positive tumor cell lines and primary chronic lymphocytic leukemia cells, and eliminated human lymphoma xenografts in ...