Maternal stress is a major risk factor for preterm birth (PTB), with recent mouse studies highlighting the role of FKBP51 in stress-induced PTB. This study identifies the 15dPGJ2-mediated inhibition ...

Seven-transmembrane receptors (7TMRs), also known as G protein-couple receptors, are the largest class of transmembrane receptors and a common target for therapeutics. Initially thought to signal ...

For example, antibody-drug conjugates use targeted antibodies to deliver highly cytotoxic drugs directly to tumor sites, while receptor ligand peptides armed ... Japan have developed a ...

Extracellular vesicles play a vital role in cell biology, modulating communication and signaling, with potential applications in diagnostics and therapeutics.

Exploration of adenosine mechanism revealed adenosine receptors as a potentially useful target of therapy in RA. Principal signaling pathways activated by adenosine receptors. AC: Adenylate ...

Pharvaris is a late-stage biopharmaceutical company developing novel, oral bradykinin B2 receptor antagonists to potentially address all types of bradykinin-mediated angioedema. Pharvaris intends to ...

Exploration of adenosine mechanism revealed adenosine receptors as a potentially useful target of therapy in RA.