Cambridge, Massachusetts-based Envisagenics focuses on using AI to analyse errors in RNA splicing, a process in which a precursor form of messenger RNA (mRNA) – which is used as a template for ...

Roivant meanwhile will stay true to its usual business model by launching a new subsidiary or 'Vant' that will take ownership of RVT-2001 and spearhead its development. The RNA splicing approach ...

"By targeting key processes like RNA splicing and modification ... from my lab and merge them with Leslie's powerful and robust model systems to nail down this novel mechanism," said co ...

RBP splicing factors are sequence-specific, binding to their cognate sequence motifs like a lock and key. “Because the binding pocket of the RBP matches the sequence motif, the RBP binds to the ...

Researchers suggest discovery of genetic link between ASD and DM1 opens up potential new therapeutic avenues for ASD.

More information: Łukasz J. Sznajder et al, Autism-related traits in myotonic dystrophy type 1 model mice are due to MBNL sequestration and RNA mis-splicing of autism-risk genes, Nature Neuroscience ...

Problems in RNA splicing can lead to “typos” that get reproduced in ... When they tested the TCRs in a preclinical model of AML, in which human tumor cells are grown in mice, they found that mice ...

The pathogenic mechanism is disruption of developmentally regulated RNA processing, primarily alternative splicing, in which failure to express ... Chi’s paper describing rescue of the mouse heart ...

Individual genes express multiple mRNAs by pre-mRNA alternative splicing, alternative polyadenylation or use of alternative promoters (first exons). As a result, individual genes express multiple ...