Stroke is said to be the second leading cause of death worldwide after heart disease. To prevent the death of neurons in the ...

Potent inhibitors of histone arginine methyltransferases such as protein arginine methyltransferase 1 (PRMT1) and PRMT4 have also been identified 146,147,148, providing further evidence that ...

The study “Identification of SARS CoV-2 Antiviral Compounds by Screening for Small Molecule Inhibitors of the nsp14 RNA Cap Methyltransferase” is available as a preprint on the bioRxiv* server ...

Protein arginine methyltransferase 5 (PRMT5) is an emerging epigenetic enzyme that mainly represses transcription of target genes via symmetric dimethylation of arginine residues on histones H4R3 ...

Amgen Inc. has described tricyclic-amido-bicyclic compounds acting as protein arginine N-methyltransferase 5 (PRMT5) inhibitors reported to be useful for the treatment of cancer.

Paper citied: "Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity," Nature Communications. DOI: 10.1038/s41467-021-23152-6 Journal ...

Protein arginine N-methyltransferase 5 (PRMT5) inhibitors have been disclosed in an Abbisko Therapeutics Co. Ltd. patent and described as potentially useful for the treatment of cancer.

Tango Therapeutics has dosed the first subject in the Phase I/II trial assessing TNG462 in combination with Revolution Medicines' daraxonrasib or zoldonrasib for methylthioadenosine phosphorylase ...

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity. Nature Communications , 2021; 12 (1) DOI: 10.1038/s41467-021-23152-6 Cite This Page : ...

Whole-genome CRISPR screens in the presence or absence of a DOT1L inhibitor revealed that concomitant targeting of the H3K4me3 methyltransferase SETD1B increases the effect of DOT1L inhibition.

Anti-leukemia activity of histone deacetylase (HDAC) inhibitor LBH589 involves depletion of EZH2 and DNA methyltransferase (DNMT) 1 through disruption of their chaperone association with heat shock ...

A new method than enables researchers to dial up or tone down the amount of a certain metastatic protein inhibitor (BACH1) within a cell could provide a new path in cancer research that reassesses ...