Rahnama'i and colleagues highlight the emerging role of selective phosphodiesterase (PDE) inhibitors in the management of functional voiding disorders. Although much remains unknown about the role ...

Two important pathologic features of pulmonary arterial hypertension are decreased endothelial nitric oxide production 14 and increased phosphodiesterase type 5 expression and activity in ...

The Recent PDE5 Inhibitors: Sildenafil, Tadalafil & Vardenafil in Male ED . Since the early 1980s and 1990s, the physiology and pathophysiology of erectile function and dysfunction have been ...

Phosphodiesterase 5 (PDE5) inhibitors (eg, sildenafil, tadalafil) do not appear to reduce the risk of Alzheimer disease and related dementias, according to a National Institutes of Health (NIH) study.

Phosphodiesterase 4 (PDE4) inhibition is associated with antiinflammatory and antifibrotic effects that may be beneficial in patients with idiopathic pulmonary fibrosis. In this phase 2, double ...

Phosphodiesterase-4 (PDE-4) inhibitors are specialty drugs doctors prescribe to treat mild to severe plaque psoriasis.They work by lowering and managing inflammation, the underlying cause of flare ...

Phosphodiesterase 4 inhibitors have only marginal benefits for people with COPD, review suggests. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2011 / 05 ...

WASHINGTON -- Treatment with the first-in-class dual phosphodiesterase 3/4 inhibitor ensifentrine reduced exacerbation rates and improved other key outcomes in patients with chronic obstructive ...

MILAN — A basket study of a new topical phosphodiesterase 4 inhibitor demonstrated efficacy superior to that of placebo in mild to moderate plaque psoriasis. PF-07038124, an oxaborole-based ...

Sidebar Key Issues. The introduction of inhibitors of the cyclic GMP phosphodiesterase (PDE) 5 into clinical urology is mainly the result of the characterization of the physiology of nonvascular ...