The sequence homology across the nuclear receptor superfamily indicates that these receptors evolved through divergent evolution 5, but gives no information about the role of ligands in the ...

A team led by researchers at the University of Toronto has discovered that a compound present in ginger selectively binds to ...

Ovulatory dysfunction is the commonest cause of female infertility. Here we show that the co-repressor nuclear-receptor-interacting protein 1 (Nrip1; encoded by the gene Nrip1) is essential for ...

In this study, the authors first used an AlphaScreen assay to identify a series of tryptophan-based cyclic peptide compounds with FXR-antagonistic activity, specifically those modified with a ...